VOLUME 6 NUMBER 1 (January to June 2013)

by Melfei E. Bungihan^1,2 , Mario A. Tan*^,1, Hiromitsu Takayama³, ThomasEdison E. dela Cruz¹, and Maribel G. Nonato¹

¹ The Graduate School and Research Center for the Natural and Applied Sciences,
   University of Santo Tomas, España, Manila 1015 Philippines
² Saint Mary's University, Bayombong, Nueva Vizcaya 3700 Philippines
³ Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana,
   Chuo-ku, Chiba 260-8675 Japan

A new macrolide, colletotriolide (1), was isolatedfrom the endophytic fungus Colletotrichum sp.isolated from Pandanus amaryllifolius by aseries of chromatographic techniques. Itsstructure was determined based on HR-MS, 1Dand 2D NMR. In addition, tyrosol C (2) isolated from the fungusColletotrichum gloeosporioides, and dothiorelone C (3) andcytosporone (4), both isolated from the fungus Chaetomiumglobosum, were also identified in this study. All three fungi wereisolated from the leaves of Pandanus amaryllifolius. Biologicalevaluation showed that 1 has a low activity against Escherichiacoli, while 4 is moderately active. Compounds 1, 3 and 4 wereinactive against the A549, HT29 and HCT116 cell lines.