Philipp. Sci. Lett. 2013 6 (1) 057-073
available online: March 15, 2013
Email Address: email@example.com
Submitted: November 6, 2012
Revised: February 19, 2013
Accepted: February 22, 2013
A new macrolide isolated from theendophytic fungus Colletotrichum sp.
by Melfei E. Bungihan1,2 , Mario A. Tan*,1, Hiromitsu Takayama3, ThomasEdison E. dela Cruz1, and Maribel G. Nonato1
1 The Graduate School and Research Center for the Natural and Applied Sciences,
University of Santo Tomas, España, Manila 1015 Philippines
2 Saint Mary's University, Bayombong, Nueva Vizcaya 3700 Philippines
3 Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana,
Chuo-ku, Chiba 260-8675 Japan
A new macrolide, colletotriolide (1), was isolatedfrom the endophytic fungus Colletotrichum sp.isolated from Pandanus amaryllifolius by aseries of chromatographic techniques. Itsstructure was determined based on HR-MS, 1Dand 2D NMR. In addition, tyrosol C (2) isolated from the fungusColletotrichum gloeosporioides, and dothiorelone C (3) andcytosporone (4), both isolated from the fungus Chaetomiumglobosum, were also identified in this study. All three fungi wereisolated from the leaves of Pandanus amaryllifolius. Biologicalevaluation showed that 1 has a low activity against Escherichiacoli, while 4 is moderately active. Compounds 1, 3 and 4 wereinactive against the A549, HT29 and HCT116 cell lines.