VOLUME 1 NUMBER 1 (January to December 2008)

De antigenization%20-%20Padlan

PSL. 2008 1 (1) 009-010
available online: July 18, 2008

DOI: https://doi.org/10.54645/CWFU32286


De-antigenization of immunodominant epitopes: A strategy for designing vaccines against constantly mutating pathogens and other applications

Eduardo A. Padlan

Marine Science Institute, College of Science,
    University of the Philippines Diliman, Quezon City, 1101, Philippines

Our immune system counters the invasion by viruses, bacteria, parasites and other pathogens, with specialized molecules and cells that eliminate or neutralize those invaders or the toxins that they produce. An important molecular arm of the immune system is composed of the antibodies which bindtightly and specifically to foreign substances (antigens). The specificity of an antibody molecule is so exquisite that it can distinguish between, for example, two protein antigens that differ by only one amino acid residue.

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