VOLUME 5 NUMBER 2 (July to December 2012)

by Eduardo A. Padlan

The Marine Science Institute, College of Science
University of the Philippines Diliman
Quezon City 1101, Philippines

Possibly useful vaccines against humanimmunodeficiency virus 1 are designed based on theinteraction of the A/E 93TH057 gp120 core, variantV65C/S115C, with antibody NIH45-46, a broadlyneutralizing antibody. The antigenicity of thisgp120 core is modified by replacing all the solvent-accessibleresidues with amino acids that are less reactive, except thoseresidues which constitute the epitope of NIH45-46. Theantibodies elicited by these vaccines are expected to be focusedon this epitope and should also be broadly neutralizing.