VOLUME 5 NUMBER 2 (July to December 2012)


Philipp. Sci. Lett. 2012 5 (2) 114-117
available online: July 20, 2012

*Corresponding author
Email Address: eduardo.padlan@gmail.com
Submitted: February 06, 2012
Revised: June 01, 2012
Accepted: June 03, 2012


Design of possibly useful vaccines againsthuman immunodeficiency virus 1

by Eduardo A. Padlan

The Marine Science Institute, College of Science
University of the Philippines Diliman
Quezon City 1101, Philippines
Possibly useful vaccines against humanimmunodeficiency virus 1 are designed based on theinteraction of the A/E 93TH057 gp120 core, variantV65C/S115C, with antibody NIH45-46, a broadlyneutralizing antibody. The antigenicity of thisgp120 core is modified by replacing all the solvent-accessibleresidues with amino acids that are less reactive, except thoseresidues which constitute the epitope of NIH45-46. Theantibodies elicited by these vaccines are expected to be focusedon this epitope and should also be broadly neutralizing.

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