VOLUME 10 NUMBER 2 (July to December 2017)
Philipp. Sci. Lett. 2017 10 (2) 089-097
available online: August 25, 2017
*Corresponding author
Email Address: arlene.bartolome@gmail.com
Date Received: May 2, 2017
Date Revised: July 30, 2017
Date Accepted: August 2, 2017
ARTICLE
Cytotoxic property of Streptocaulon baumii extracts and their isolated compounds against different human cancer cell lines
by Arlene P. Bartolome1,*, Irene M. Villaseñor1, Yea-Lih Lin2, M. Daben J. Libardo3, Alfredo M. Angeles-Boza3 and Wen-Chin Yang4,5,6,7,8
1Institute of Chemistry, University of the Philippines, Diliman, Quezon City 1101, Philippines
2Institute of Human Genetics (CNRS UPR-1142), Montpellier, France
3Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269, United States
4Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
5Institute of Pharmacology, Yang-Ming University, Taipei 112, Taiwan
6Department of Life Sciences, National Chung-Hsing University, Taichung 402, Taiwan
7Institute of Zoology, National Taiwan University, Taipei 106, Taiwan
8Department of Aquaculture, National Taiwan Ocean University, Keelung 20224, Taiwan
2Institute of Human Genetics (CNRS UPR-1142), Montpellier, France
3Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269, United States
4Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
5Institute of Pharmacology, Yang-Ming University, Taipei 112, Taiwan
6Department of Life Sciences, National Chung-Hsing University, Taichung 402, Taiwan
7Institute of Zoology, National Taiwan University, Taipei 106, Taiwan
8Department of Aquaculture, National Taiwan Ocean University, Keelung 20224, Taiwan
Investigation of the antiproliferative property of Streptocaulon baumii Decne. (Apocynaceae) leaves showed that the hexane fraction nonselectively inhibits cell proliferation of BJ, A549, HCT116 and MCF-7 cell lines using WST-1 cell proliferation assay. In a bioassay- guided scheme, loliolide (1), luteolin 3ʹ-methoxy ether (2) and ursolic acid (3) were isolated. MTT assay indicated that ursolic acid has the highest cytotoxicity against HeLa, MDA-MB231, Cos7 and RAW264.7. The IC50 of the purified compounds against a panel of cell lines is in the low micromolar range. This is the first report on the cytotoxicity of S. baumii against cancer cells as well as the first report of the isolation of the three compounds from plants of the Streptocaulon genus.
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