Role of FGF23 and alkaline phosphatase in bone health: Case-based clinico-physiologic discussion

Sandoval, Mark Anthony S.; Tabu, Irewin A.

VOLUME 17 (Supplement)

SciEnggJ%202024%20Special%20Issue%20148 154 Maarof%20et%20al

SciEnggJ 17 (Supplement) 188-193
available online: June 05, 2024
DOI: https://doi.org/10.54645/202417SupCTT-11

*Corresponding author
Email Address: mssandoval1@up.edu.ph
Date received: February 15, 2024
Date revised: April 18, 2024
Date accepted: April 26, 2024

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ARTICLE

Role of FGF23 and alkaline phosphatase in bone health: Case-based clinico-physiologic discussion

Mark Anthony S. Sandoval*^1,2 and Irewin A. Tabu³

¹Department of Physiology, College of Medicine, University of the
     Philippines Manila
²Division of Endocrinology, Diabetes and Metabolism, Department
     of Medicine, College of Medicine and Philippine General
     Hospital, University of the Philippines Manila
³Department of Orthopedics, College of Medicine and Philippine
     General Hospital, University of the Philippines Manila

KEYWORDS: Fibroblast growth factor 23, alkaline phosphatase, bone, fracture, osteomalacia

Proper bone development requires the coordinated and calibrated action of various cells, hormones, enzymes and nutrients. In this paper, we present two clinical cases of metabolic bone disorders – one with excessive fibroblast growth factor-23 (FGF23) and the other, with low alkaline phosphatase. FGF23 and alkaline phosphatase are not-so-well-known players in bone health. This paper puts the spotlight on these two, and discusses their role in bone development, and how abnormal levels lead to disease.